Dry Mouth and Associated Complications

Cesar Migliorati, Professor and Chair

Course date: Wednesday, July 11, 2012 08:00 PM (EST)
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Saliva is critical for maintenance of good oral health. Key actions of saliva include: buffering to prevent an acidic oral environment which predisposes to dental demineralization and supply of calcium and phosphate, key substrates for dental remineralization, and protein secretion that enhances the local defenses against infection. Dry mouth can develop due to salivary gland hypofunction or due to pathological dysfunction of the glands. In the general population there are about 10% of individuals with dry mouth. In individuals over 65 years of age, about 20-25% complain of dry mouth. In nursing homes up to 50% of individuals can have dry mouth.

Saliva is important for communication and nutrition and hyposalivation can significantly alter quality of life. In this presentation we will discuss causes that may lead to dry mouth and associated complications to oral and general health. Common conditions include diabetes and hormonal changes, depression and anxiety, radiation therapy of the head and neck that includes salivary glands in the radiation fields, and some autoimmune diseases like Sjögren’s Syndrome.

For instance, hyposalivation develops shortly after initiation of radiation therapy and persists long term when doses to the salivary glands exceeds 3000 cGy. Patients with chronic hyposalivation are at risk for oral cavity infections and dental caries. Depending on the extent of hyposalivation and the oral environment, a severe form of rapidly developing decay can lead to loss of dentition. Current concepts regarding the management of patients with dry mouth will complete the discussion.

Note: LIVE attendance is limited and will be issued on a first-come, first-serve basis. Nonetheless, all registrants will have access to the on-demand recoring of this lecture. Thanks for your understanding.

Presenter Disclosure: Dr. Caesar Migliorati received an honorarium from Colgate-Palmolive to compensate for the time involved preparing and giving this presentation. 

Target audience: Dentists, Hygienists and Assistants.

Release date: Wednesday, July 11, 2012
Expiration date: Saturday, July 11, 2015

"Dry Mouth and Associated Complications" is co-sponsored by Dental Tribune America, LLC. Dental Tribune America LLC is a recognized ADA CERP provider.

The speaker will answer your questions

Maite Moreno
19 May 2012, 09:18 AM (EST)
Will you please describe how is detected cancer of Mamary glands in saliva?? or is this matter of another topic.
Thank you. Maite Moreno DDS, MS (Mexico)
Dr. Cesar Migliorati Professor and Chair
09 July 2012, 10:28 AM (EST)
Hi, this is a subject for another talk. However you can search PUBmed under saliva and cancer and you will find information about it. The link below takes you to a recent paper from the UCLA group

http://www.ncbi.nlm.nih.gov/pubmed/22746063
Jessica Twibell
25 June 2012, 07:38 PM (EST)
I deal with especially very poor patients and cancer patients (and sometimes they are both). I see xerostomia complications often, and I am always looking for (1) new, inexpensive, and practical educational tips, and (2) product lines easily available at local stores (versus online, etc). Thank you, Jessica Twibell, RDH (Colorado, USA)
Dr. Cesar Migliorati Professor and Chair
09 July 2012, 10:39 AM (EST)
The education of patients with xerostomia does not change if you are rich or poor. Thus, what we have been doing over the years is what I still recommend to my patients. There are several places where on can find tips and orientation. One could search the site of the National Cancer Institue under oral complications of cancer therapies. There you will find information about patients who have been treated with radiation of the head and neck and who have severe xerostomia. This information could be used for any patient.

I am recommending biotine products. The oral balance gel is the best for patients with dry mouth. Keeping good oral hygiene and using high fluoride content toothpaste is also importan to prevent caries.
Ursula F.
03 July 2012, 11:03 AM (EST)
I've been looking for a course like this for a while. Thanks for this opportunity to attend.
Dr. Cesar Migliorati Professor and Chair
09 July 2012, 10:39 AM (EST)
Thanks. I hope you like the course.
Nancy Oxsen
05 July 2012, 09:28 PM (EST)
Wish this could be later for west coast people. I have a commute and get off at 5:00. Try to get it at the office or at another location.
Dr. Cesar Migliorati Professor and Chair
09 July 2012, 10:40 AM (EST)
Sorry. Hope you can get home on time.
Julia Wehkamp
09 July 2012, 01:37 PM (EST)
Hi Nancy! Please be aware, that this live broadcast will be recorded and made available to you within a few days, so that you may review it at your convenience. Should you you have any questions or concerns for Dr. Migliorati while viewing the archive, you may post them here.
Thanks for your interest!
Fleur Wheeler
11 July 2012, 07:27 PM (EST)
Thanks for offering this course . Can't wait for new information.
Dr. Cesar Migliorati Professor and Chair
13 July 2012, 10:11 AM (EST)
Thanks for attending! Cesar
John Virag DMD,MSd
11 July 2012, 08:46 PM (EST)
Thank you Dr. for such an informative course on this important topic to help care for our patients in pain.
I appreciate it.
Dr. Cesar Migliorati Professor and Chair
13 July 2012, 10:12 AM (EST)
Dear John,

I am so happy that you had the chance to atend the webinar. I hope all is well with you. Hope to have a chance to see you again soon. Best, Cesar
Nancy Best
11 July 2012, 09:03 PM (EST)
what is the best regimen for nighttime drymouth patients?
Dr. Cesar Migliorati Professor and Chair
13 July 2012, 10:13 AM (EST)
I recommend the patient to brush teeth with a high fluoride content toothpaste before going to bed, rinse well with an antisseptic rinse, and use oral balance gell as needed. I also have the patient have a humidifier by the bed and drinking water.
Nancy Best
11 July 2012, 09:19 PM (EST)
Thanks so much!
Katarzyna Danko
11 July 2012, 09:55 PM (EST)
Thank you for a very valuable information about xerostomia. I wonder if you could help me with my question about xerostomic patient who complains about the lack of lubrication. Which salivary glands are most likely to be responsible for the lack of lubrication? Are they minor (accessory) glands which are responsible for production of 70% mucins in mouth? Sublingual and submandibular as they assure unstimulated salivary flow? I know parotids generate saliva on stimulation. Does "lack of lubrication" mean the same as " decreased salivary flow" ? English is not my first language and understanding the difference really confuses me. I would be very greatful for you help. Katarzyna Danko, DMD.
Dr. Cesar Migliorati Professor and Chair
13 July 2012, 10:18 AM (EST)
It is difficult to determine what gland is respondible for the dryness of the mouth. This is only possible in the case of head and neck radiation therapy when we know which glands were irradiated. When radiation is not involved, I guess that all salivary glands are involved, like in the case of patients who take medications that cause dry mouth. Lack of lubrication meas that there is not enough saliva to provide the necessary lubrication of the oral mucosa. Keep in mind that all salivary glands, both major and minor, have a very important role in the production of saliva and the maintenance of oral health. It is important that all of the glands are healthy for maximun protection of the oral cavity.
Linda Percell
13 July 2012, 05:12 PM (EST)
In answering the questions on the quiz, it states which diseases can cause hyposalivation. I answered Sjogrens because my impression is that depression and stress don't cause dry mouth, but the medications taken for these diseases can. Am I mistaken in this thinking?

Linda Percell, RDH, MHSc
JO ANN SNIDER
20 July 2012, 12:53 PM (EST)
Linda,

I think you will find that depression and the meds to treat it, and stress do actually make dry mouth worse. I've seen patient under major stress who never had dry mouth previously come in with all the issues we see in our Sjogren's and other dry mouth patients--heavier plaque build up, more calcium deposits, increased inflammation which is disproportional to the actual plaque volume.

I am a dental hygienist with Primary Sjogren's, so dealing with dry mouth is something I do on a daily basis. For me there is the option of sialogogues like Salagen/Pilocarpine and Evoxac to stimulate more saliva production. For patients who are dry from medications and other problems, increasing salivary output by stimulating saliva with sugar-free mints or gum is often helpful if they still can make reasonable amounts of saliva. For super dry folks, mineral paste can help neutralize the acidic saliva by using it every four hours during the day. I'm also a fan of mineral paste fluoride varnish treatments because they supply all the necessary building blocks to tooth repair instead of relying of inadequate ambient salivary minerals to work.
JoAnn RDH, BSDH, Primary Sjogren's Advocate
catherine groenlund
16 July 2012, 11:48 AM (EST)
Do you use the Biotene Mouth rinse in a spray bottle. I find regularly fine spraying the mouth as needed when uncomfortable helps with dryness feelings, Catherine
catherine groenlund
16 July 2012, 11:54 AM (EST)
Please do you use Biotene Mouth rinse in a spray bottle and the patient sprays a little as required. I have had good results with this
Catherine
joseph salkowitz
19 July 2012, 09:56 AM (EST)
Dear Dr. Migliorati, I enjoyed your webinar the other day and would like your view on the use of Gelclair for dry mouth. I know it is not available in the US but would consider having it compounded for my patient.

Joe Salkowitz, DMD
rebecca wieczorek
22 August 2012, 08:03 PM (EST)
Dear Dr. Migliorati,

Thank you for offering this course I enjoyed it. Is there any thought about why zerostomia is effecting more people in the United States than others?

Rebecca

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Cesar Migliorati , Professor and Chair

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Cesar A. Migliorati, received a dental degree from the University of Sao Paulo (USP), Brazil in 1972 and a MS in Stomatology. He worked as a dentist in private practice and was a teacher at USP in the Stomatology Department. Between 1981 and 1984 he completed specialty training in Oral Medicine and a Master’s Degree in Oral Biology at UC San Francisco (UCSF). In 1988 he obtained board certification in Oral Medicine. Dr. Migliorati has held teaching positions at USP, UCSF, University of Florida, University of Zurich and Nova Southeastern University.

He completed a PhD in stomatology with emphasis in HIV/AIDS in 2002. Dr. Migliorati has worked in Oral Medicine for the past 25 years in teaching, research and patient care. He was one of the pioneering professionals to work with patients suffering from oral manifestations of HIV/AIDS. He has also worked with patients with oral mucosal inflammatory diseases, oral infections, oral precancer and cancer and the oral complications of cancer therapy.

His research in oral precancer and cancer, immunology, HIV infection and immunosuppression, oral mucositis and laser therapy is thought provoking. He is a member of the American Academy of Oral Medicine and the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology. Dr. Migliorati’s letter to the editor of the Journal of Clinical Oncology in 2003 was the first report in the medical literature of bisphosphonate osteonecrosis. He has published extensively in medical and dental journals that include JCO, Lancet Oncology and Nature Reviews Endocrinology.

 

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