Artificial Intelligence Applied to Dental Medicine

Ira Lamster DDS, MMSc

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Artificial Intelligence Applied to Dental Medicine

Artificial intelligence (AI) refers to development of machines that function and perform tasks analogous to those performed by humans. The field of AI began after the Second World War and has seen periods of great interest as well as disinterest and skepticism1Horgan j. Will artificial intelligence ever live up to its hype? Scientific american. Retrieved from: Https://www.Scientificamerican.Com/article/will-artificial-intelligence-ever-live-up-to-its-hype/ on december 6, 2020.. Recently, AI has attracted new attention, in large part due to advances in computer technology. Other important terms used in this context are “machine learning” (ML) which refers to an aspect of AI that uses algorithms to identify patterns in data sets and thereby predict such patterns in other data, and “deep learning” (DL), which is an aspect of ML that mimics the functions of the human brain, with its neural networks. What is implied here is that there are multiple levels within the system, and hence the “deep” descriptor2Schwendicke F, Samek W, Krois J. Artificial intelligence in dentistry: Chances and challenges. J Dent Res. 2020;99(7):769-74..

Interest in the application of AI in many aspects of society reflects the computing power, availability of large databases from which information can be mined, as well as the potential for removing human error from decision-making situations. We see evidence of AI in our daily lives. When you make a purchase on-line, and then receive follow-up messages offering similar products for sale, AI is at work.

The application of AI to healthcare is one obvious area of study and has experienced recent growth. This has occurred in several clinical fields. As examples in medicine, consider ophthalmology and diagnostic radiology.

Figure 1.

Ophthalmology

A recent review highlighted the application of AI in the identification of several eye disorders, including diabetic retinopathy, glaucoma, and age-related macular degeneration3Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, et al. Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol. 2019;103(2):167-75.. Diabetic retinopathy (DR) is a clinical complication of diabetes, and it has been estimated that approximately one-third of patients with diabetes will develop this disorder. DR is identified using a variety of techniques that visualize the retina at the back of the eye (Figure 1). Screening is recognized as an important tool for early detection of DR, and referral for treatment to prevent blindness. The performance of AI/DL systems to detect DR has been shown to be was very good. Sensitivity (the percent of positive cases that are identified) ranged from 87% to 100%, and specificity (the percentage of negative cases that are identified) ranged from 73% to 98%. These results were seen with evaluation of existing data sets where the outcome is known. More recently, real-world clinical program assessments yielded comparably impressive results. Other studies have shown similar outcomes when AI/DL systems were used for identification of glaucoma and age-related macular degeneration.

The potential benefit of these systems for identification of DR is obvious. These techniques can be used as cost-saving approaches to screen patients with diabetes in resource poor countries and remote areas where an ophthalmologist is not available. These techniques could be linked to telemedicine for diagnosis and initiation of treatment.

However, challenges to implementation exist. These include the need to determine accuracy in different populations, standardization of image capture, application in other common (cataract) and rare (tumors) conditions, physician acceptance, medical-legal issues, and re-imbursement.

Diagnostic Radiology

The use of AI has been extensively examined in relation to medical imaging. Research has shown that AI systems are extremely effective at identification of the complex patterns that characterize many medical images, and can provide quantitative analysis of these patterns, with the intent of identifying abnormalities, primarily associated with disease4Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts H. Artificial intelligence in radiology. Nat Rev Cancer. 2018;18(8):500-10..

A good example of the application of AI to diagnostic radiology is the chest x-ray. Since this image is commonly used throughout the world, existing data sets are available for evaluation. A review of the agreement between DL systems and experienced radiologists indicated close agreement, but that radiologists in different institutions may not agree as closely5Yasaka K, Abe O. Deep learning and artificial intelligence in radiology: Current applications and future directions. PLoS Med. 2018;15(11):e1002707.. Another study examined agreement as to identification of COVID-19 pneumonia. COVID-19 infection was verified by the reverse transcription polymerase chain reaction (223 positive, 231 negative). The AI system correctly identified COVID-19 pneumonia on radiographs with approximately 80% accuracy. This degree of accuracy was comparable to that achieved by independent radiologists who read the films6Murphy K, Smits H, Knoops AJG, Korst M, Samson T, Scholten ET, et al. Covid-19 on chest radiographs: A multireader evaluation of an artificial intelligence system. Radiology. 2020;296(3):E166-E72..

These studies provide examples of the potential application of AI and DL in medical care. Nevertheless, while this technology holds great promise7Mintz Y, Brodie R. Introduction to artificial intelligence in medicine. Minim Invasive Ther Allied Technol. 2019;28(2):73-81., this technology has not seen widespread clinical application in medicine8Rajkomar A, Dean J, Kohane I. Machine learning in medicine. N Engl J Med. 2019;380(14):1347-58.. The application of AI to dentistry has been studied, offering intriguing possibilities, and today the introduction of AI in clinical dentistry is on the horizon.

Application of AI to Dentistry

Several reviews have examined the application of AI to dentistry. Park and Park9Park WJ, Park JB. History and application of artificial neural networks in dentistry. Eur J Dent. 2018;12(4):594-601. emphasize that AI in healthcare offers to aid in decision-making, thereby allowing non-specialists to function as specialists in different fields. While the potential application of AI to different healthcare disciplines would seem limitless, most of the work has been in diagnosis and identification of risk and outcomes. Another review of the application of AI to dentistry tallied the potential applications that have begun to be evalued in a variety of dental specialties (adopted from Machoy et al.10Machoy ME, Szyszka-Sommerfeld L, Vegh A, Gedrange T, Wozniak K. The ways of using machine learning in dentistry. Adv Clin Exp Med. 2020;29(3):375-84.). These include:

Orthodontics:

  1. decision-making regarding the need for tooth extraction.
  2. prediction of tooth size of unerupted teeth.
  3. management of impacted canine teeth.
  4. cephalometric diagnosis.
  5. production of skeletal malocclusion related to mandibular morphology.

Restorative dentistry and prosthodontics:

  1. predicting restoration longevity.
  2. color matching for esthetic restorations.
  3. design of removable partial dentures.
  4. predicting the outcome of tooth-whitening procedures.

Periodontology and oral medicine:

  1. diagnosis and classification of periodontal disease.
  2. use of immunologic parameters to diagnosis aggressive periodontitis.
  3. classification of halitosis based on identification of periodontal pathogens in saliva.
  4. predicting recurrence of aphthous ulcers.

Temporomandibular joint disorders (TMD):

  1. use of magnetic resonance imaging to determine the prognosis of TMD.
  2. use of screening questions to aid in treatment of TMD.
  3. identification of subgroups of internal derangement of the temporomandibular joint.

Endodontics:

  1. location of accessory canals.
  2. detection of periapical radiolucencies11Endres MG, Hillen F, Salloumis M, Sedaghat AR, Niehues SM, Quatela O, et al. Development of a deep learning algorithm for periapical disease detection in dental radiographs. Diagnostics (Basel). 2020;10(6)..

Oral and Maxillofacial Surgery:

  1. detection of root fractures.
  2. clinical decision support for treatment with dental implants.

Oral Cancer:

  1. prognosis of oral cancer considering lesion histology and genetic characteristics.
  2. assessment of hyper-nasal speech following treatment of oral/oropharyngeal cancer.
  3. risk assessment for oral cancer.

Until recently, AI applications in clinical dentistry have been limited to research studies, but commercial applications that will impact clinical care are now being introduced. This is occurring primarily in the field of oral and maxillofacial radiology. This practical application is logical because imaging is essential to diagnosis and treatment of dental diseases and images are collected over time (allowing for assessment of disease progression). Further, the most common dental diseases (caries and periodontal diseases) occur throughout the world, so databases are available for ML. These large databases are needed for development and training of the system to recognize deviations from normal.

Why have AI applications not been adopted by the dental profession? The reasons include lack of availability of data due to patient privacy concerns, as well as lack of completeness of patient records, difficulty in defining the “gold standard”, i.e., what is normal and what is disease, and the available outcome provides only some of the data needed to develop a complete approach to treatment. The next decade will determine if the promise offered by application of AI in dentistry can be realized, which ultimately will result in improved care, for a greater number of individuals, and at a reduced cost.

A review of the application of AI for dental imaging suggest that the most common uses for AI in dental radiology will be for cephalometric analysis, identification of osteoporosis, identification of cysts and tumors of the jaws, as well as identification of periodontal and periapical disease12Hung K, Montalvao C, Tanaka R, Kawai T, Bornstein MM. The use and performance of artificial intelligence applications in dental and maxillofacial radiology: A systematic review. Dentomaxillofac Radiol. 2020;49(1):20190107..

It appears that the broader introduction of AI into clinical dentistry will occur with interpretation of two-dimensional radiographs. Several start-up companies have developed systems to identify the anatomy, existing restorations and abnormal findings/pathology on bitewing and periapical films, as well as panoramic radiographs. (see Figures 2 and 3).

These programs will scan radiographs, and can identify the anatomy [i.e., tooth number, crowns, cementoenamel junction, root length, distance from the cementoenamel junction (CEJ) to the crest of the alveolar bone], as well as abnormal/pathologic findings (i.e., periodontal disease as an indicated by increased distance from the CEJ to the alveolar crest, caries, the presence of a periapical radiolucency and root fractures). This identification can serve as an internal check on the clinician’s assessment of the radiographs, and it is claimed, thereby free up time to allow the dentist to spend more time with patients. From the perspective of large multi-practice organizations (i.e., dental service organizations), this technology can also enhance quality control across multiple offices. It is also expected that dental insurance companies will utilize this technology to assure that adequate documentation (quality of the radiographs) is provided, and determine if the request for benefits is within guidelines.

The application of AI in dentistry for analysis of 3-dimensional imaging also is on the horizon13Hung K, Yeung AWK, Tanaka R, Bornstein MM. Current applications, opportunities, and limitations of ai for 3d imaging in dental research and practice. Int J Environ Res Public Health. 2020;17(12).. The expansion of the use of three-dimensional imaging, specifically cone beam computed tomography (CBCT), offers intriguing opportunities for the application of AI. The much greater amount of information contained in CBCT scans require more of the clinician’s time to fully analyzed the images. In this case, the use of AI will certainly improve efficiency and clinical accuracy.

There are, however, challenges. These include hesitancy of providers to adopt new approaches to practice and patient management. This is also the concern regarding the accuracy of the programs, as research reports describing the accuracy and validity of these programs are generally lacking. Another concern is cost and reimbursement.

There are several companies that now offer AI related to radiographic interpretation. Websites are provided below, which provide more information about the services that are offered. (No endorsement of any of these companies should be implied).

Company Website
Overjet www.overjet.ai
Denti www.denti.ai
VideaHealth www.videa.ai
Pearl www.hellopearl.com
Orca www.orca-dental.ai
Retrace www.retrace.ai

The introduction of AI in dentistry is now gaining momentum, especially in these times of re-imagining clinical care and considering new ways to engage patients. While questions remain, a tipping point seems to have been reached that will bring AI into routine dental care. A review of potential applications and benefits suggest that the value added by the introduction of AI systems for radiographic interpretation in dental offices will provide the following:

  1. The identification of deviations from normal, specifically dental and osseous pathology. As such, this serves as a quality control measure. The findings will undoubtedly need to be matched with clinical data.
  2. Greater ease of tracking changes in radiographs over time.
  3. Improved efficiency within the practice. The findings can be linked to practice management software, and insurance claims can even be generated at the conclusion of the patient visit.
  4. Integration of medical and dental practices will be enhanced. This will depend in part on linkage of medical and dental electronic patents records. With this linkage dental providers will be able to see patient characteristics that can impact dental disease and treatment, i.e., diagnosis of diabetes, smoking status, and smoking history. Conversely, medical providers can have access to information in the dental record that may impact chronic disease, i.e., severity of periodontal disease.
  5. Improved patient relations as the introduction of these systems will build patient/provider trust.
  6. Introduction of these systems will differentiate practices, with a focus on adoption of new technology.
  7. Potential exists for using these systems to help educate students and younger members of the profession in radiographic interpretation.

All oral health care providers should be informed about the available (commercial) systems and understand what each can offer. In the ideal, these systems should improve the quality of care in a time-efficient manner.

Legends for Figures

Figure 1. Fundus photography of the retina. Fundus photography provides a visual image of the internal surface of the eye (retina). This technique is used to identify abnormalities associated with a variety of eye disorders, including diabetic retinopathy. AI can be used to identify these abnormalities when a specialist in not available. The top photograph is a normal retina and changes associate with diabetic retinopathy are seen in the lower photograph. The complex microvascular anatomy is well suited to analysis by AI.
Figure 2. Bitewing radiograph analyzed by an AI system identifies deviations from normal. In this system restorative findings (compromised margin of a restoration, dental caries), periodontal findings (reduced height of alveolar bone, furcation involvement) as well as existing restorations, are noted to the right. Image courtesy of Dr. Wardah Inam (Overjet.ai).
Figure 3. Panoramic radiograph analyzed by an AI system identifies deviations from normal. In this system deviations are listed by tooth number to the right. The percentages reflect the probability of that finding being present. Image courtesy of Dr. Eric Pulver (Denti.ai).

References

  • 1.Horgan j. Will artificial intelligence ever live up to its hype? Scientific american. Retrieved from: Https://www.Scientificamerican.Com/article/will-artificial-intelligence-ever-live-up-to-its-hype/ on december 6, 2020.
  • 2.Schwendicke F, Samek W, Krois J. Artificial intelligence in dentistry: Chances and challenges. J Dent Res. 2020;99(7):769-74.
  • 3.Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, et al. Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol. 2019;103(2):167-75.
  • 4.Hosny A, Parmar C, Quackenbush J, Schwartz LH, Aerts H. Artificial intelligence in radiology. Nat Rev Cancer. 2018;18(8):500-10.
  • 5.Yasaka K, Abe O. Deep learning and artificial intelligence in radiology: Current applications and future directions. PLoS Med. 2018;15(11):e1002707.
  • 6.Murphy K, Smits H, Knoops AJG, Korst M, Samson T, Scholten ET, et al. Covid-19 on chest radiographs: A multireader evaluation of an artificial intelligence system. Radiology. 2020;296(3):E166-E72.
  • 7.Mintz Y, Brodie R. Introduction to artificial intelligence in medicine. Minim Invasive Ther Allied Technol. 2019;28(2):73-81.
  • 8.Rajkomar A, Dean J, Kohane I. Machine learning in medicine. N Engl J Med. 2019;380(14):1347-58.
  • 9.Park WJ, Park JB. History and application of artificial neural networks in dentistry. Eur J Dent. 2018;12(4):594-601.
  • 10.Machoy ME, Szyszka-Sommerfeld L, Vegh A, Gedrange T, Wozniak K. The ways of using machine learning in dentistry. Adv Clin Exp Med. 2020;29(3):375-84.
  • 11.Endres MG, Hillen F, Salloumis M, Sedaghat AR, Niehues SM, Quatela O, et al. Development of a deep learning algorithm for periapical disease detection in dental radiographs. Diagnostics (Basel). 2020;10(6).
  • 12.Hung K, Montalvao C, Tanaka R, Kawai T, Bornstein MM. The use and performance of artificial intelligence applications in dental and maxillofacial radiology: A systematic review. Dentomaxillofac Radiol. 2020;49(1):20190107.
  • 13.Hung K, Yeung AWK, Tanaka R, Bornstein MM. Current applications, opportunities, and limitations of ai for 3d imaging in dental research and practice. Int J Environ Res Public Health. 2020;17(12).