Colgate Oral Health Network
Offenbacher Symposium Podcast Series – Part 2: Periodontal Medicine/Oral-Systemic Connection
J. Max Goodson Rachel Mascari Souvik Sen Kim A. Boggess Mark I. Ryder
J. Max Goodson DDS, PhD, Rachel Mascari MS, Souvik Sen MD, MS, MPH, FAHA, Kim A. Boggess MD, Mark I. Ryder DMD

This podcast discusses the concept of “disease reciprocity” and proposes a mechanism that might link gingivitis and obesity, based on metabolomic analysis.

After completing this podcast, listeners should be able to:

  • Comprehend the suggested reciprocal pathogenic relationship between gingivitis and obesity.
J. Max Goodson

J. Max Goodson DDS, PhD

Numerous studies indicate that periodontal disease significantly increases the risk of primary ischemic stroke and subsequent cardiovascular events. This presentation provides an overview of these studies, along with a review of the different stroke types and subtypes.

After completing this podcast, listeners should be able to:

  • Categorize stroke types and subtypes and describe several reported associations between periodontal disease and ischemic stroke.
Rachel Mascari

Rachel Mascari MS

Souvik Sen

Souvik Sen MD, MS, MPH, FAHA

Periodontal disease is a risk factor for various adverse pregnancy outcomes. This presentation addresses four specific adverse outcomes associated with maternal periodontitis and stresses the importance of promoting oral health and oral health prophylaxis during pregnancy.

After completing this podcast, listeners should be able to:

  • Name several adverse pregnancy outcomes associated with periodontal disease and describe a potential mechanism linking periodontal infection to these outcomes.
Kim A. Boggess

Kim A. Boggess MD

Over the past 15+ years, a possible association between Alzheimer disease (AD) and periodontitis has emerged. This presentation describes the role that P. gingivalis might play in linking these two inflammatory and degenerative diseases. A promising new therapeutic option for both periodontal disease and AD, currently being evaluated in clinical trials, is also discussed.

After completing this podcast, listeners should be able to:

  • Identify a potential mechanistic link between periodontitis and Alzheimer disease, as well as a new promising approach to treat both diseases.
Mark I. Ryder

Mark I. Ryder DMD

J. Max Goodson

J. Max Goodson DDS, PhD

More courses with J. Max Goodson

Dr. J. Max Goodson was born in Lubbock, Texas and raised on a Texas ranch. He received a bachelor’s degree in Chemistry from Texas Tech University (1962), a dental degree (D.D.S.) from the University of Texas Dental Branch, and a master’s degree in dental research and a Ph.D. in Pharmacology from the University of Rochester (1970).

He taught Pharmacology for seven years at the University of California, San Francisco, where he became a full professor. Here, he identified PGE2 as a component of periodontal disease and elucidated the danger in treatment of pedodontics patients with narcotics (especially alphaprodine) combined with local anesthetics.

In 1976, he joined the faculty of The Forsyth Institute in Boston to work with Sigmund Socransky in the Periodontal Research Center and received an appointment in the Harvard School of Dental Medicine. In this environment, he published evidence for an episodic periodontal disease hypothesis and developed the first FDA-approved local drug delivery system for periodontal disease therapy (Actisite®).

In a five-year clinical study (2012-2017) of adolescent obesity and diabetes of Kuwaiti children (n=8,317), he identified elevated salivary levels in obese children of 1-methyl-2 pyridone-5 carboxamide (2PY), a product associated with low-level consumption of uranium suggesting that obesity in Kuwait could be the result of military contamination occurring during the Gulf War. In that study of adolescent obesity in children with and without gingivitis, he reported data suggesting that salivary levels of the amino acid hydroxyproline, an effect commonly associated with collagen destruction, suggests that obesity and gingivitis may interact with each other. He is now Senior Member of the Staff Emeritus of The Forsyth Institute and Associate Clinical Professor at the Harvard School of Dental Medicine.

Financial disclosure: J. Max Goodson has received an honorarium from Colgate-Palmolive Company.
Rachel Mascari

Rachel Mascari MS

More courses with Rachel Mascari

Rachel Mascari earned her Bachelor of Science in Biochemistry and Molecular Biology at the University of South Carolina and her Master of Science in Physiology and Biophysics from Georgetown University. She is currently a medical student in the Class of 2022 at the University of South Carolina in Columbia, South Caroline. Following graduation, she plans to pursue residency training in Neurology. She is actively engaged in research in the role of infection and inflammation in pathophysiology of cerebrovascular disease.

Financial disclosure: Rachel Mascari has received an honorarium from Colgate-Palmolive Company.
Souvik Sen

Souvik Sen MD, MS, MPH, FAHA

More courses with Souvik Sen

Souvik Sen received his graduate medical degree (1990) from University of Calcutta, Master of Public Health degree (2009) in Epidemiology from the Gillings School of Public Health at the University of North Carolina (UNC), Chapel Hill, and Master of Science degree (1993) in Cardiovascular Pharmacology from Wayne State University in Detroit, Michigan. He completed his Neurology Residency (1997) at Temple University in Philadelphia and his Post-Doctoral fellowship (1998) in Cerebrovascular Diseases (Stroke) from the Johns Hopkin’s Medical Institution in Baltimore, Maryland.

In 2002, Dr. Sen founded the Stroke Center at UNC Chapel Hill. In 2010, he joined as the founding Chair and Tenured Professor of the Department of Neurology at the University of South Carolina School of Medicine. From 2018-2020, he served as President of the South Carolina Neurology Association.

Dr. Sen has received several grants from the National Institutes of Health (NIH). He is currently the principal investigator in the NIH-funded PREMIERS study, an ongoing randomized clinical trial investigating the role of treatment of periodontal disease in secondary stroke prevention. He is currently an affiliated faculty for the UNC Center for Oral Systemic Disease

Financial disclosure: Souvik Sen has received an honorarium from Colgate-Palmolive Company.
Kim A. Boggess

Kim A. Boggess MD

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Kim A. Boggess is Professor of Ob/Gyn and Maternal Fetal Medicine at the University of North Carolina at Chapel Hill. Her clinical and research expertise focuses on infection and inflammation complicating pregnancy. Her prior accomplishments include preclinical and clinical studies defining the relationship between maternal oral infection, inflammation, and adverse pregnancy outcomes.

Dr. Boggess has successfully managed and conducted multi-center trials, funded by both the National Institutes of Health and by industry. She was co-investigator of a multicenter clinical study to determine the optimal antibiotic strategy to prevent maternal and infant post-cesarean infectious complications, Principal Investigator for a longitudinal study of markers for preeclampsia and spontaneous preterm birth, and Principal Investigator of a pharmacokinetic study of 17-hydroxyprogesterone for preterm birth prevention. She has also completed research using large databases, including a MarketScan® Claims Database analysis of the association of treatment choice in gestational diabetes on adverse pregnancy outcomes and an examination of the utility of Tdap vaccination during pregnancy. Currently, she is Co-Investigator for an NHLBI-funded multicenter trial of hypertension treatment complicating pregnancy and the Co-Principal Investigator for an NICHD-funded multicenter trial of treatment of type 2 diabetes in pregnancy.

Dr. Boggess completed her MD training at the State University of Stony Brook, her Ob/Gyn residency training at the University of Washington, her Maternal Fetal Medicine Fellowship training at Duke University, and her Certificate in Health Disparities Research at the University of North Carolina at Chapel Hill.

Financial disclosure: Kim A. Boggess has received an honorarium from Colgate-Palmolive Company.
Mark I. Ryder

Mark I. Ryder DMD

More courses with Mark I. Ryder

Dr. Mark Ryder is a Professor of Periodontology and former Chair of the Division of Periodontology and Director of the Postgraduate program in Periodontology at the University of California, San Francisco, where he has been a faculty member for the past 42 years. He received his dental and specialty training from the Harvard School of Dental Medicine. He has lectured extensively on a variety of research and educational topics. His current research interests include connections between periodontal diseases and Alzheimer’s Disease, the links between oral and systemic health in HIV patients, and basic and clinical trials on novel periodontal therapies. He has received awards from both the University of California and from national organizations for his entertaining and informative lectures, and for his contributions to dental education.

Financial disclosure: Mark I. Ryder has received an honorarium from Colgate-Palmolive Company.
Language: EnglishC.E. credits: 1Start date: March 18, 2022Expiration date: March 18, 2025AGD PACE subject code(s): 490