Colgate Oral Health Network
Offenbacher Symposium Podcast Series – Part 1: Periodontal Disease: Inflammation & Pathogenesis
Julie T. Marchesan Kenneth S. Kornman Thomas E. Van Dyke
Julie T. Marchesan DDS, PhD, Kenneth S. Kornman DDS, PhD, Thomas E. Van Dyke DDS, PhD

This podcast collection pays tribute to the late Dr. Steven Offenbacher, a renowned periodontal researcher who is considered the “father of periodontal medicine.” During his 40-year career, Dr. Offenbacher investigated the mechanisms of periodontitis and its links to other diseases. The speakers in this series have previously collaborated with Dr. Offenbacher or taken inspiration from his work, and they offer unique perspectives on their latest research related to inflammation and pathogenesis, periodontal medicine, and precision oral health. The podcasts are based on their papers published in a special Journal of Periodontology supplement dedicated to Dr. Offenbacher and supported by Colgate-Palmolive Company.

Periodontitis is a complex, multifactorial inflammatory disease. Genome-wide association study (GWAS) analysis has revealed several single nucleotide polymorphisms and genes associated with periodontal disease. This podcast discusses two of these genes and how their activation contributes to periodontal disease.

After completing this podcast, listeners should be able to:

  • Define single nucleotide polymorphisms and identify two inflammasome genes with polymorphisms that are associated with increased severity of periodontal disease.
Julie T. Marchesan

Julie T. Marchesan DDS, PhD

Elevated low-grade systemic inflammation, driven by specific cytokines, influences some common chronic diseases, including cardiovascular disease, and may inform how periodontal disease influences certain common chronic diseases. New perspectives on chronic inflammation are shared in this presentation.

After completing this podcast, listeners should be able to:

  • Identify several prevalent, low-grade chronic inflammatory diseases that increase an individual’s systemic inflammatory burden and put the individual at risk for other diseases.
Kenneth S. Kornman

Kenneth S. Kornman DDS, PhD

Our understanding of the pathogenesis of periodontal disease has evolved significantly over the past several decades. This podcast reviews these paradigm shifts, along with new treatment strategies that are being evaluated in pre-clinical studies. Specifically, specialized pro-resolving mediators (SPMs) are discussed.

After completing this podcast, listeners should be able to:

  • Explain the major paradigm shifts that have occurred over the past several decades in understanding the pathogenesis and treatment of periodontal disease
Thomas E. Van Dyke

Thomas E. Van Dyke DDS, PhD

Julie T. Marchesan

Julie T. Marchesan DDS, PhD

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Dr. Julie Marchesan, DDS, PhD is an Assistant Professor at the Adams School of Dentistry, University of North Carolina at Chapel Hill. She is a clinician-scientist who completed her DDS at the University of Sao Paulo in 2003 and PhD at the University of Michigan in 2013. Dr. Marchesan has received numerous research honors and awards by industry, the National Institutes of Health, and the American Association for Dental, Oral, and Craniofacial Research. Dr. Marchesan’s research focuses on understanding the periodontal host response and how immune heterogeneity contributes to periodontal disease development. The main goal of her research is to develop specific adjuvant therapies for periodontitis-afflicted individuals based on the principles of precision oral care

Financial disclosure: Julie T. Marchesan has received an honorarium from Colgate-Palmolive Company.
Kenneth S. Kornman

Kenneth S. Kornman DDS, PhD

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Dr. Kornman is Editor-in-Chief of the Journal of Periodontology and Adjunct Research Professor in the Department of Periodontics and Oral Medicine at the University of Michigan. Previously, Dr. Kornman was cofounder and Chief Scientific Officer of Interleukin Genetics, a diagnostics company focused on chronic inflammatory diseases, including periodontitis, cardiovascular disease, and osteoarthritis. Dr. Kornman is currently CEO of a molecular diagnostics company based in London. Prior to entering industry, he was Professor and Chairman of Periodontology and Professor of Microbiology and Immunology at the University of Texas Health Science Center at San Antonio. Dr. Kornman has published extensively, including papers in Science, New England Journal of Medicine, Journal of American College of Cardiology, Human Molecular Genetics, Annals of Rheumatic Diseases, and various dental journals. Much of Dr. Kornman’s career has focused on translating research into clinical use. This includes several issued U.S. patents and multiple years of assessing new technology generated within the Division of Genomic Medicine at the University of Sheffield Medical School in the UK. Dr. Kornman received his DDS from Emory University, as well as a specialty in periodontology and a PhD from the University of Michigan. His mentors were Sig Ramfjord and Harald Löe.

Financial disclosure: Kenneth S. Kornman has received an honorarium from Colgate-Palmolive Company.
Thomas E. Van Dyke

Thomas E. Van Dyke DDS, PhD

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Thomas Van Dyke, DDS, PhD is Senior Vice President for Clinical and Translational Research and Senior Member of Staff at the Forsyth Institute in Cambridge, MA. He is also Professor of Oral Medicine, Infection, and Immunity at Harvard University Faculty of Medicine. He received his DDS from Case Western Reserve University, his PhD in Oral Biology, MS in Oral Sciences, and Periodontics Certificate from the State University of New York at Buffalo, and was awarded two degrees honoris causa from Justus Liebig University Giessen and University of Copenhagen. He is a member of the American/International Association of Dental Research, American Academy of Periodontology, International Academy of Periodontology, American Association for the Advancement of Science, American Society of Microbiology, IADR Periodontal Research Group, American Dental Association, and American Association of Immunologists.

Dr. Van Dyke has received the Balint Orban Memorial Prize for Research in Periodontology, the IADR Award for Basic Research in Periodontology, the Norton Ross Award for Excellence in Clinical Research, the William J. Gies Periodontology Award, and the American Academy of Periodontology Distinguished Scientist Award. He serves on numerous editorial boards and has edited two volumes of Periodontology 2000. He is Diplomate of the American Board of Periodontology and served as President of the International Association of Periodontology from 1997 to 1999.

Dr. Van Dyke has published 370+ original articles, as well as numerous abstracts and book chapters. His research interests are the structural and functional relationship of abnormalities of the inflammatory process, with focus on phagocytic cells and microorganisms in the etiology and pathogenesis of periodontal and other infectious-inflammatory diseases. Dr. Van Dyke is also involved in clinical research and clinical trials focusing on drug treatment for periodontal disease and local delivery systems. The remainder of his time is devoted to training fellows and administration. He is best known for his work on the pathogenesis of juvenile periodontal diseases, resolution of inflammation in periodontitis, and clinical research.

Financial disclosure: Thomas E. Van Dyke has received an honorarium from Colgate-Palmolive Company.
Language: EnglishC.E. credits: 0.75Start date: March 18, 2022Expiration date: March 18, 2025AGD PACE subject code(s): 490